Atrial Fibrillation

Atrial fibrillation (AFib) is an arrhythmia condition of the heart's upper chambers. It can cause serious complications, including stroke, and significantly impact a patient's quality of life.

An irregular heart rhythm

Some people have no symptoms. Others notice palpitations, shortness of breath or fatigue. A clinician can assess symptoms and confirm a diagnosis.

  • Palpitations or a racing heartbeat

  • Shortness of breath

  • Fatigue or reduced stamina

Source: National Heart, Lung, and Blood Institute: Atrial fibrillation.

Continuing the search

Current care can include medicines, ablation procedures and stroke-risk management. Thryv is exploring SGK1 inhibition as a potential medical treatment for cardiac arrhythmias, including AFib.

AFib can occur in isolation, but more often occurs alongside other heart disease, including heart failure. In ASPIRE-HF, a history of paroxysmal AFib is allowed and heart rhythms will be monitored. This may allow an exploratory analysis of the effects of THRV-1268 on AFib burden.

Thryv supports the importance of understanding the clinical meaningfulness of AFib burden and is proud to be a member of the AF-B-STEP Consortium.